                         SEQUENCE LISTING

<110>  MacroGenics, Inc.
       Ferguson, Stacey
       Koenig, Scott
       Tuaillon, Nadine
       Johnson, Leslie S
       Huang, Ling
       Rankin, Christopher
 
<120>  COMPOSITION AND METHOD OF TREATING CANCER WITH AN ANTI-UROPLAKIN 
       IB ANTIBODY

<130>  48024-0004WO

<160>  16    

<170>  PatentIn version 3.3

<210>  1
<211>  120
<212>  PRT
<213>  murine

<400>  1

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Ile Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asp Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Ala Gly Thr Gly Pro Trp Leu Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  2
<211>  360
<212>  DNA
<213>  murine

<400>  2
caggtccaac tgcagcagcc tggggctgag ctggtgaggc ctgggtcttc agtgaaggtg     60

tcctgcaagg cctctggcta caccttcagc agctattgga tgcattgggt gaagcaaagg    120

cctatacaag gccttgaatg gattggtaac attgaccctt ctgatagtga aactcactac    180

aatcaaaagt tcaaggacaa ggccacattg accgtagaca aatcctccag cacagcctac    240

atgcagctca gcagcctgac atctgaggac tctgcggtct attactgtgc aagatcgggg    300

gctgggacgg gcccctggct tgcttactgg ggccaaggga ctctggtcac tgtctctgca    360


<210>  3
<211>  113
<212>  PRT
<213>  murine

<400>  3

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Asn Pro Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  4
<211>  339
<212>  DNA
<213>  murine

<400>  4
gacattgtga tgacacagtc tccatcctcc ctgactgtga cagcaggaga gaaggtcact     60

atgacctgca agtccagtca gagtctgtta aacagtggaa atcaaaagaa ctacttgacc    120

tggtaccagc agaaaccagg gcagcctcct aatccgttga tctactgggc atccactagg    180

gaatctgggg tccctgatcg cttcacaggc agtggatctg gaacagattt cactctcacc    240

atcagcagtg tgcaggctga agacctggca gtttattact gtcagaatga ttatagttat    300

ccattcacgt tcggctcggg gacaaagttg gaaataaaa                           339


<210>  5
<211>  123
<212>  PRT
<213>  murine

<400>  5

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asn Thr Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Glu Ser Met 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Arg Gln Gly Asp Gly Tyr Tyr Val Gly Trp Phe Ala Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120             


<210>  6
<211>  369
<212>  DNA
<213>  murine

<400>  6
gaggtgcagc ttgttgagtc tggtggagga ttggtgcagc ctaaagggtc attgaaactc     60

tcatgtgcag cctctggatt cagcttcaat acctacgcca tgaactgggt ccgccaggct    120

ccaggaaagg gtttggaatg ggttgctcgc ataagaagta aaagtaataa ttatgcaaca    180

tattatgccg attcagtgaa agacagattc accatctcca gagatgattc agaaagcatg    240

ctctatctgc aaatgaacaa cttgaaaact gaggacacag ccatgtatta ctgtgtgaga    300

cagggggatg gttactacgt gggctggttt gcttactggg gccaagggac tctggtcact    360

gtctctgca                                                            369


<210>  7
<211>  107
<212>  PRT
<213>  murine

<400>  7

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  8
<211>  321
<212>  DNA
<213>  murine

<400>  8
gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc     60

atcagttgca gggcaagtca ggacattagc aattatttaa actggtatca gcagaaacca    120

gatggaactg ttaaactcct gatctactac acatcaagat tacactcagg agtcccatca    180

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa    240

gaagatattg ccacttactt ttgccaacag ggtaatacgc ttccattcac gttcggctcg    300

gggacaaagt tggaaataaa a                                              321


<210>  9
<211>  22
<212>  DNA
<213>  artificial sequence

<220>
<223>  SJ15R Primer

<400>  9
ggtcactgtc actggctcag gg                                              22


<210>  10
<211>  28
<212>  DNA
<213>  artificial sequence

<220>
<223>  SJ16R Primer

<400>  10
aggcggatcc aggggccagt ggatagac                                        28


<210>  11
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  SJ17R Primer

<400>  11
gcacacgact gaggcacctc cagatg                                          26


<210>  12
<211>  34
<212>  DNA
<213>  artificial sequence

<220>
<223>  SJ18R Primer

<400>  12
cggcggatcc gatggataca gttggtgcag catc                                 34


<210>  13
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  13

Gln Arg Asp Phe Phe Thr Pro Asn Leu Phe Leu Lys Gln Met Leu Glu 
1               5                   10                  15      


Arg Tyr Gln Asn Asn Ser Pro Pro Asn Asn Asp Asp Gln Trp Lys Asn 
            20                  25                  30          


Asn Gly Val Thr Lys Thr Trp Asp Arg Leu Met Leu Gln Asp Asn Cys 
        35                  40                  45              


Cys Gly Val Asn Gly Pro Ser Asp Trp Gln Lys Tyr Thr Ser Ala Phe 
    50                  55                  60                  


Arg Thr Glu Asn Asn Asp Ala Asp Tyr Pro Trp Pro Arg Gln Cys Cys 
65                  70                  75                  80  


Val Met Asn Asn Leu Lys Glu Pro Leu Asn Leu Glu Ala Cys Lys Leu 
                85                  90                  95      


Gly Val Pro Gly Phe Tyr His Asn Gln Gly Cys Tyr Glu Leu Ile Ser 
            100                 105                 110         


Gly Pro Met Asn Arg His Ala Trp Gly 
        115                 120     


<210>  14
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  14

Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230             


<210>  15
<211>  354
<212>  PRT
<213>  artificial sequence

<220>
<223>  UPK-G1 fusion protein

<400>  15

Gln Arg Asp Phe Phe Thr Pro Asn Leu Phe Leu Lys Gln Met Leu Glu 
1               5                   10                  15      


Arg Tyr Gln Asn Asn Ser Pro Pro Asn Asn Asp Asp Gln Trp Lys Asn 
            20                  25                  30          


Asn Gly Val Thr Lys Thr Trp Asp Arg Leu Met Leu Gln Asp Asn Cys 
        35                  40                  45              


Cys Gly Val Asn Gly Pro Ser Asp Trp Gln Lys Tyr Thr Ser Ala Phe 
    50                  55                  60                  


Arg Thr Glu Asn Asn Asp Ala Asp Tyr Pro Trp Pro Arg Gln Cys Cys 
65                  70                  75                  80  


Val Met Asn Asn Leu Lys Glu Pro Leu Asn Leu Glu Ala Cys Lys Leu 
                85                  90                  95      


Gly Val Pro Gly Phe Tyr His Asn Gln Gly Cys Tyr Glu Leu Ile Ser 
            100                 105                 110         


Gly Pro Met Asn Arg His Ala Trp Gly Val Glu Pro Lys Ser Cys Asp 
        115                 120                 125             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    130                 135                 140                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
145                 150                 155                 160 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                165                 170                 175     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            180                 185                 190         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
        195                 200                 205             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    210                 215                 220                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
225                 230                 235                 240 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                245                 250                 255     


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
            260                 265                 270         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        275                 280                 285             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    290                 295                 300                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
305                 310                 315                 320 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                325                 330                 335     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            340                 345                 350         


Gly Lys 
        


<210>  16
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  proteinase digestion site

<400>  16

Asp Asp Asp Asp Lys Leu Glu 
1               5           


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DC\633141\1
 

